Heat Shock Response
Heat shock genes encode molecular chaperones and other cytoprotective molecules that prevent accumulation of damaged proteins. In eukaryotes, synthesis of heat shock proteins (HSPs) is regulated primarily at the level of transcription by a master activator HSF1.
We identified a nucleoprotein complex, containing the translation elongation factor eEF1A1 and a non-coding RNA that is required for HSF1 activation. We also showed that eEF1A1 orchestrates the entire process of heat shock response (HSR), from the transcriptional activation of heat shock genes to the stabilization, transport, and translation of their mRNAs. We continue to investigate the complex mechanism of HSR at transcriptional and post-transcriptional levels.
The results of our studies will have implications for numerous physiological conditions associated with protein misfolding, including various types of cancer and neurodegenerative diseases.