Mechanisms of Cellular Stress Responses

Our lab studies fundamental issues concerning cellular adaptation to genotoxic and proteotoxic stress. In particular, we attempt to understand how cells rapidly detect damage to their macromolecules (DNA and proteins) to promptly activate corrective processes. The failure to react appropriately has major pathological and evolutionary consequences, such as mutagenesis, cellular transformation, aging, and cell death. We use various model systems, including bacteria, nematodes, and mammalian cells to study these processes, and have developed powerful genomic, proteomic, and analytical tools that enhance our research capabilities.